Scientific research

Neuromodulators in regulation of phosphorylation processes of synaptosomal membrane proteins.

The role of phosphorylation and dephosphorylation of plasma membrane calcium pump by serine/threonine protein kinases in maintenance of calcium homeostasis in neuronal cells.

Characterisctics of neuroactive steroids action on ion-dependent ATPases in vivo and in vitro in synaptosomal membranes of the selected rat brain regions.

Non-genomic regulation of plasma membrane calcium pump activity by neuroactive steroids.

The effects of reactive oxygen and nitrogen species on structure and function of calcium pump in excitable and non-excitable cells.

Magnesium sulphate therapy in treatment of asphyxiated newborns.

The effects of prenatal magnesium sulphate treatment of very low weight preterm newborns on the selected parameters of erythrocyte membranes.

Regulation of cellular calcium homeostasis during growth and development of pheochromocytoma PC12 cell line by neuroactive steroids.

Disturbance of calcium homeostasis in neuronal cells under oxidative stress - the role of glutathione-S-transferases.

Regulation of protein tyrosine kinases activity by angiotensins in normal and transformed pituitary cell lines.

Most important publications (2005 - 2011)

Original papers

Vinitskaya H, Lachowicz A, Kilanowicz A, Bartkowiak J, Żylińska L (2005)  Prolonged exposure to polychlorinated naphthalenes affects GABA-metabolizing enzymes in rat brain. Environ Toxicol Pharmacol, 20, 450-455

Szemraj J, Sobolewska B, Gulczynska E, Wilczynski J, Żylińska L (2005)  Magnesium sulfate effect on erythrocyte membranes of asphyxiated newborns. Clin Biochem, 38, 457-464

Rebas E, Lachowicz-Ochedalska A (2005)  The effect of angiotensin III on protein tyrosine kinase activity in rat pituitary. Regul Pept, 130, 14-8

Rebas E, Lachowicz L, Lachowicz A. (2005)  Estradiol modulates the synapsins phosphorylation by various protein kinases in the rat brain under in vitro and in vivo conditions. J Physiol Pharmacol, 56, 39-48

Gulczynska E, Gadzinowski J,Wilczynski J, Zylinska L (2006)  Prenatal MgSO4 treatment modifies the erythrocyte band 3 in preterm neonates. Pharmacol Res, 53, 347-352

Zylinska L, Kozaczuk A, Szemraj J, Kargas Ch, Kowalska I (2007)  Functional importance of PMCA isoforms in growth and development of PC12 cells. Ann N Y Acad Sci, 1099, 254-269

Cooper DR, Boczek T, Grelewska K, Pinkowska M, Sikorska M, Zawadzki M, Derewenda Z (2007)  Protein crystallization by surface entropy reduction: optimization of the SER strategy. Acta Cryst D63,636–645

Zylinska L, Gulczynska E,, Kozaczuk A (2008)  Changes in erythrocyte glutathione and plasma membrane calcium pump in preterm newborns antenatally treated with MgSO4. Neonatology, 94, 4, 272-278

Zylinska L, Kowalska I, Kozaczuk A (2008)  Fast action of neuroactive steroids on plasma membrane calcium pump in PC12 cells. Ann. N Y Acad Sci, 1148

Żylińska L, Kowalska I, Ferenc B. (2009)  Calmodulin effect on steroid-regulated plasma membrane calcium pump. Cell Biochem Func, 27, 111-117

Derewenda U, Boczek T, Gorres KL, Yu M, Hung LW, Cooper D, Joachimiak A, Raines RT, Derewenda ZS (2009) Structure and function of Bacillus subtilis YphP, a prokaryotic disulfide isomerase with a CXC catalytic motif. Biochemistry 48, 8664-8671

Sobczak M, Boczek T, Ferenc B, Taha J, Kozaczuk A, Wiktorska M, Sacewicz-Hofman I, Niewiarowska J, Żylińska L (2010)  Functional characteristic of PC12 cells with reduced microsomal glutathione transferase 1. Acta Biochim Pol, 57, 589-96

Boczek T, Kozaczuk A, Taha J, Ferenc B, Żylińska L (2010)  Adaptation of microsomal glutathione transferase 1 in PC12 cells with modified PMCA isoforms composition. Indian J Biochem Biophys, 47, 265-271

Kosiorek M, Podszywalow-Bartnicka P, Zylinska L, Zablocki K, Pikula S. (2011)  Interaction of Plasma Membrane Ca2+-ATPase isoform 4 with calcineurin A: implications for catecholamine secretion by PC12 cells. Biochem Biophys Res Commun, 411, 235-240

Kowalski A, Żylińska L, Boczek T, Rębas E (2011)  GABA-shunt enzymes activity in GH3 cells with reduced level of PMCA 2 or PMCA 3 isoform. Biochem Biophys Res Commun, 411, 815-820

Boczek T, Kozaczuk A, Ferenc B, Kosiorek M, Pikula S, Żylińska L (2011)  Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin. Mol Cell Biochem, (in press)